Dynamic Drug Screening Platform
The Caco-2 assay is the gold standard for in vitro drug permeability assessment throughout the pharmaceutical industry. However, it's static, and does not reflect the dynamic in vivo environment it sets out to simulate. Peristalsis plays a key role in absorption of compounds in the gut.
By incorporating MICA technology, we have developed a new DYNAMIC Caco-2 assay add-on which is simple and easy to align with the current protocols for drug screening using the standard Caco-2 assay. The assay itself remains mostly unchanged, with a small addition to the protocol by mechanically stimulating the cells.
Get in touch below to request a demo or quote!
Beta testing with our partners Xenogesis (now part of Sygnature Discovery) found: