Dynamic Drug Screening Platform
We support new approaches to drug screening, by providing a better analogue for the in vivo environment - all without having to change your current procedures!
The Caco-2 assay is the gold standard for in vitro drug permeability assessment throughout the pharmaceutical industry. However, it's static and does not reflect the dynamic in vivo environment it sets out to simulate. Peristalsis plays a key role in absorption of compounds in the gut and our technology simulates this.
By incorporating MICA technology, we have developed a new DYNAMIC Caco-2 assay add-on which is simple and easy to align with the current protocols for drug screening using the standard Caco-2 assay. The assay itself remains mostly unchanged, with a small addition to the protocol by mechanically stimulating the cells.
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Beta testing with our partners Xenogesis (now part of Sygnature Discovery) found:
Dynamic drug absorption in Caco-2 cells can be up to 150% greater than static absorption assays
Phase 4 compounds which showed limited absorption in static assays show absorption in our DYNASCREEN™ assays
DYNASCREEN™ is the first dynamic Caco-2 drug screening assay of its kind to better predict in vivo human drug absorption rates