The Caco-2 assay is the gold standard for in vitro drug permeability assessment throughout the pharmaceutical industry. This assay, however, has weaknesses and does not mimic the in vivo environment where peristalsis plays a key role in absorption of compounds into the gut. By incorporating MICA technology, we have developed a new DYNAMIC Caco-2 assay which is simple and easy to align with the current protocols for drug screening using the standard Caco-2 assay.
Innovate UK funding has allowed beta testing with our partners Xenogesis where we have found:
Dynamic drug absorption in Caco-2 cells can be up to 150 % greater than static absorption assays
Phase 4 compounds which shows limited absorption in static assays show absorption in our DYNASCREEN assays
Dynascreen™ is the first dynamic Caco-2 drug screening assay of its kind to better predict in vivo human drug absorption rates.